These nanodevices open new possibilities to a wide range of applications in medical diagnostics at the point of care, global health, molecular imaging, biology research, ultra-high throughput screening, and investigations of the therapeutic action of pharmaceutical agents. Fiberoptics-based nanobiosensors are used to detect apoptotic processes in single cells following photodynamic cancer treatment or to monitor pH in cancer cells. These studies demonstrate applications of plasmonics “molecular sentinel” nanoprobes for diagnostics of diseases such as cancer and the use of nano-biosensors for measurements of molecular signaling pathways inside a single cell. Novel nanobiosensors and nanoprobes combining bio-recognition and nanotechnology have been developed for in-vitro molecular diagnostics and in-vivo monitoring of biological targets and biochemical processes in a single living cell. The presentation describes two areas of research related to the development of nanoprobes and nanosensors for biomolecule detection and single-cell analysis : (1) plasmonics nanoprobes using surface-enhanced Raman scattering (SERS) detection and (2) nanobiosensors for in vivo analysis of a single cell for molecular diagnostics and imaging, and ultra-high throughput screening.
This lecture presents an overview of recent advances in the development of optical nanobiosensor and nanoprobe technology at the nexus of engineering, biology, medicine and nanotechnology. Supply systems, dams, oil and gas pipelines and other facilities, and can be integrated with wireless networks.
Theĭistributed optical fiber sensor has been applied to the power grids, railways, bridges, tunnels, roads, constructions, water
Materials, smart structure, and smart skill) system, which is easy to construct smart fiber sensor networks. The distributed optical fiber sensor network (Rayleigh, Raman, and Brillouin scattering) is a 3S (smart Sensor networks are important components of the Wavelength shifter, a new type of Brillouin optical time domain analyzers (BOTDA) integrated with a fiber RamanĪmplifier, distributed fiber Raman and Brillouin sensors integrated with a fiber Raman amplifier, and distributed fiberīrillouin sensors integrated with a fiber Brillouin frequency shifter. Temperature sensors based on a pulse coding source, distributed fiber Raman temperature sensors using a fiber Raman Generation distributed fiber sensors are investigated and designed, which consist of new generation ultra-long distributedįiber Raman and Rayleigh scattering sensors integrated with a fiber Raman amplifier (FRA), auto-correction fullĭistributed fiber Raman temperature sensors based on Raman correlation dual sources, distributed fiber Raman The ability of multi-parameter measurements, and the intelligence of distributed fiber sensor systems, a new generationįiber sensor technology based on the optical fiber nonlinear scattering fusion principle is proposed. In order to improve the measurement distance, the accuracy, the space resolution, Additionally, a closed-loop operation has been demonstrated by locking both the frequencies of clockwise (CW) and counter clockwise (CCW) travelling lightwaves to the resonator's resonant frequencies with manipulating the serrodyne waveform.Ī brief review of recent progress in researches, productions and applications of distributed fiber Raman sensors at China To suppress the backscattering induced noise effectively, a precise adjustment of amplitude of the bipolar digital serrodyne waveform has also been introduced. An automated control to optimize the suppression has been proposed and demonstrated in experiments. In this paper, a resonator made of a polarization-maintaining optical fiber (PMF) with twin 90o polarization-axis rotated splices has been proposed to suppress the polarization-fluctuation induced drift. Because the sensing fiber length in R-FOG is much shorter than that in interferometer FOG (I-FOG), the Shupe effect, which is caused by temporally variant temperature distribution along the fiber, can effectively be reduced in R-FOG. The serrodyne modulation serves multiple functions from reducing noises caused by fiber characteristics, such as backscattering and optical Kerr effect, to achieving gyro signal processing including closed-loop operation. We have proposed and studied a resonator fiber optic gyro (R-FOG) with bipolar digital serrodyne phase modulation scheme.
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